Caffeine increases Nr1i3 expression and potentiates the effects of its ligand, TCPOBOP, in mice liver

Caffeine increases Nr1i3 expression and potentiates the effects of its ligand, TCPOBOP, in mice liver

<p>Caffeine is one of the world's most consumed substances. It is present in coffee, green tea and guarana, among others. The xenobiotic-sensing nuclear receptor subfamily 1, group I, member 3 (Nr1i3), also known as the Constitutive Androstane Receptor (Car) is a key regulator of drug met...

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Bibliographic Details
Main Authors: Heidge Fukumasu, Arina Lázaro Rochetti, Andreia Oliveira Latorre, Pedro Ratto Lisboa Pires, Tereza Cristina Silva, Maria Lucia Zaidan Dagli
Format: Article
Language:English
Published: Universidade de São Paulo 2015-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Cafeína/efeitos/estudo experimental
Receptor constitutivo de androstano/efeitos da cafeína
1,4-<italic>bis</italic>-[2-(3,5-dicloropiridiloxi)]benzeno,3,3,5,5-tetracloro-1,4-<italic>bis</italic>(piridiloxi)benzeno
Citocromo p450
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200295&lng=en&tlng=en

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