Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

Abstract Background In mammals, specification of primordial germ cells (PGCs) is established in the early post­implantation embryo. The bone morphogenetic protein (BMP)-SMAD and WNT3-β-catenin signaling initiate the gene regulatory network for PGC specification. The activation of SOX17-BLIMP1 axis i...

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Bibliographic Details
Main Authors: Fang Fang, Zili Li, Qian Zhao, Chengliang Xiong, Ke Ni
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Stem Cell Research & Therapy
Subjects:
Primordial germ cells
Induced pluripotent stem cells
BMP
EpCAM
INTEGRINα6
Lineage genes
Online Access:http://link.springer.com/article/10.1186/s13287-020-01620-y

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http://link.springer.com/article/10.1186/s13287-020-01620-y

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