Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model

Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model

Abstract Background The immunomodulation of the antitumor response driven by immunocheckpoint inhibitors (ICIs) such as PD-L1 (Programmed Death Ligand-1) monoclonal antibody (α-PD-L1) have shown relevant clinical outcomes in a subset of patients. This fact has led to the search for rational combinat...

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Bibliographic Details
Main Authors: María Merino, Teresa Lozano, Noelia Casares, Hugo Lana, Iñaki F. Troconiz, Timo L. M. ten Hagen, Grazyna Kochan, Pedro Berraondo, Sara Zalba, María J. Garrido
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Nanobiotechnology
Subjects:
Liposome
PD-L1
Doxorubicin
Chemo-immunotherapy
Immunotherapy
Immunogenic cell death
Online Access:https://doi.org/10.1186/s12951-021-00846-z

Internet

https://doi.org/10.1186/s12951-021-00846-z

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