Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night ca...

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Bibliographic Details
Main Authors: Shogo Haraguchi, Masaki Kamata, Takuma Tokita, Kei-ichiro Tashiro, Miku Sato, Mitsuki Nozaki, Mayumi Okamoto-Katsuyama, Isao Shimizu, Guofeng Han, Vishwajit Sur Chowdhury, Xiao-Feng Lei, Takuro Miyazaki, Joo-ri Kim-Kaneyama, Tomoya Nakamachi, Kouhei Matsuda, Hirokazu Ohtaki, Toshinobu Tokumoto, Tetsuya Tachibana, Akira Miyazaki, Kazuyoshi Tsutsui
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
steroid
allopregnanolone
pineal gland
Purkinje cell
light-at-night
Online Access:https://elifesciences.org/articles/45306

Internet

https://elifesciences.org/articles/45306

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