PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

Prostate cancer (PCa) is the second most common malignancy among men in the world. Castration-resistant prostate cancer (CRPC) is the lethal form of the disease, which develops upon resistance to first line androgen deprivation therapy (ADT). Emerging evidence demonstrates a key role for the PI3K-AK...

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Bibliographic Details
Main Authors: Merritt P Edlind, Andrew C Hsieh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-06-01
Series:Asian Journal of Andrology
Subjects:
androgen receptor; CRPC; kinase inhibitors; mTOR; prostate cancer; PI3K; resistance
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=3;spage=378;epage=386;aulast=Edlind

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=3;spage=378;epage=386;aulast=Edlind

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