Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

Most DNA in the genomes of higher organisms does not code for proteins. RNA Polymerase II (Pol II) transcribes non-coding DNA into long non-coding RNAs (lncRNAs), but biological roles of lncRNA are unclear. We find that mutations in the yeast lncRNA CUT60 result in poor growth. Defective termination...

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Bibliographic Details
Main Authors: Dorine Jeanne Mariëtte du Mee, Maxim Ivanov, Joseph Paul Parker, Stephen Buratowski, Sebastian Marquardt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
RNA Polymerase II
lncRNA
Transcriptional Interference
Chromatin
Pervasive transcription
Genome Stability
Online Access:https://elifesciences.org/articles/31989

Internet

https://elifesciences.org/articles/31989

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