Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.

Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) synthase (NOS) and NO production. Akita mice, a genetic non-obese type 1 diabetes model, recapitulate human diabetes. We determ...

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Bibliographic Details
Main Authors: Haroldo A Toque, Kenia P Nunes, Lin Yao, Zhimin Xu, Dmitry Kondrikov, Yunchao Su, R Clinton Webb, Ruth B Caldwell, R William Caldwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747112?pdf=render

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http://europepmc.org/articles/PMC3747112?pdf=render

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