Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production

Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production

The neglected tropical infirmity Chagas disease (CD) presents high mortality. Its etiological agent T. cruzi is transmitted by infected hematophagous insects. Symptoms of the acute phase of the infection include fever, fatigue, body aches, and headache, making diagnosis difficult as they are present...

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Bibliographic Details
Main Authors: Sergio M. Borghi, Victor Fattori, Thacyana T. Carvalho, Vera L. H. Tatakihara, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro, Camila R. Ferraz, Larissa Staurengo-Ferrari, Rubia Casagrande, Wander R. Pavanelli, Fernando Q. Cunha, Thiago M. Cunha, Phileno Pinge-Filho, Waldiceu A. Verri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
pain
glial cells
NFκB
cytokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.539086/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.539086/full

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