High Oncolytic Activity of a Double-Deleted Vaccinia Virus Copenhagen Strain against Malignant Pleural Mesothelioma

High Oncolytic Activity of a Double-Deleted Vaccinia Virus Copenhagen Strain against Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a cancer of the pleura that lacks efficient treatment. Oncolytic immunotherapy using oncolytic vaccinia virus (VV) may represent an alternative therapeutic approach for the treatment of this malignancy. Here, we studied the oncolytic activity of VV thymidine k...

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Bibliographic Details
Main Authors: Tiphaine Delaunay, Joelle Nader, Marion Grard, Isabelle Farine, Vera Hedwig, Johann Foloppe, Thibaut Blondy, Mathilde Violland, Daniel Pouliquen, Marc Grégoire, Nicolas Boisgerault, Philippe Erbs, Jean-François Fonteneau
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic immunotherapy
oncolytic virus
vaccinia virus
pleural mesothelioma
thymidine kinase
ribonucleotide reductase
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301285

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http://www.sciencedirect.com/science/article/pii/S2372770520301285

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