Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1) and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 in mouse models of Alzheimer's disease have opposing effects on amyloid-β and tau pathologies raising concerns about...

Full description

Bibliographic Details
Main Authors: Suzanne E. Hickman, Elizabeth K. Allison, Uwanda Coleman, Nathan D. Kingery-Gallagher, Joseph El Khoury
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
microglia
Alzheimer's disease
CX3CR1
Aβ-degrading enzymes
fractalkine
chemokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02780/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02780/full

Similar Items