PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin

PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin

Human atherosclerotic plaque contains smooth muscle cells (SMCs) negative for the contractile phenotype (α-smooth muscle actin) but positive for proprotein convertase subtilisin/kexin type 9 (PCSK9). Thus, we generated rat SMCs which overexpressed human PCSK9 (SMCs<sup>PCSK9</sup>) with...

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Bibliographic Details
Main Authors: Maria Giovanna Lupo, Silvia Marchianò, Maria Pia Adorni, Francesca Zimetti, Massimiliano Ruscica, Maria Francesca Greco, Alberto Corsini, Nicola Ferri
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
PCSK9
smooth muscle cells
statins
cholesterol
HMG-CoA reductase
Online Access:https://www.mdpi.com/1422-0067/22/8/4114

Internet

https://www.mdpi.com/1422-0067/22/8/4114

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