Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants

Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants

Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses. Other major advantages of OVs are that they dose-escalate in tumors and can be gen...

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Bibliographic Details
Main Authors: Adil Mohamed, Randal N. Johnston, Maya Shmulevitz
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
reovirus
oncolytic virus
cancer
attachment
uncoating
replication
reverse genetics
Online Access:http://www.mdpi.com/1999-4915/7/12/2936

Internet

http://www.mdpi.com/1999-4915/7/12/2936

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