Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone

A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor function. From the pioneering work of Hans Selye, w...

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Bibliographic Details
Main Authors: Pierrick ePoisbeau, Florence eKeller, Maya eAouad, Nisrine eKamoun, Ghislaine eGroyer, Michael eSchumacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hyperalgesia
Nociception
Pain
allodynia
Neurosteroids
etifoxine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00174/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00174/full

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