Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer.

Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer.

BACKGROUND:Triple-negative breast cancer (TNBC) is a highly diverse group that is associated with an aggressive phenotype. Its treatment has been challenging due to its heterogeneity and absence of well-defined molecular targets. Thus, there is an urgent need to identify novel agents with therapeuti...

Full description

Bibliographic Details
Main Authors: Ritu Arora, Clayton Yates, Bernard D Gary, Steven McClellan, Ming Tan, Yaguang Xi, Eddie Reed, Gary A Piazza, Laurie B Owen, Windy Dean-Colomb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4045585?pdf=render

Internet

http://europepmc.org/articles/PMC4045585?pdf=render

Similar Items