Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells

Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells

Our previous findings have demonstrated that autophagy regulation can alleviate the decline of learning and memory by eliminating deposition of extracellular beta-amyloid peptide (Aβ) in the brain after stroke, but the exact mechanism is unclear. It is presumed that the regulation of beta-site APP-c...

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Bibliographic Details
Main Authors: Rong-fu Chen, Ting Zhang, Yin-yi Sun, Ya-meng Sun, Wen-qi Chen, Nan Shi, Fang Shen, Yan Zhang, Kang-yong Liu, Xiao-jiang Sun
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; brain Injury; oxygen-glucose deprivation; cerebral ischemia; stroke; autophagy; beta-site APP-cleaving enzyme 1 (BACE1); beta-amyloid peptide; 3-methyladenine (3-MA); Rapamycin; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1433;epage=1440;aulast=Chen

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1433;epage=1440;aulast=Chen

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