Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory

Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory

Nav1.2, a voltage-gated sodium channel subunit encoded by the Scn2a gene, has been implicated in various brain disorders, including epilepsy, autism spectrum disorder, intellectual disability, and schizophrenia. Nav1.2 is known to regulate the generation of action potentials in the axon initial segm...

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Bibliographic Details
Main Authors: Wangyong Shin, Hanseul Kweon, Ryeonghwa Kang, Doyoun Kim, Kyungdeok Kim, Muwon Kang, Seo Yeong Kim, Sun Nam Hwang, Jin Yong Kim, Esther Yang, Hyun Kim, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
sodium channel
neuronal excitability
synaptic transmission
synaptic plasticity
learning and memory
autism
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00145/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00145/full

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