Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer

Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer

<p>Abstract</p> <p>Background</p> <p>The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer...

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Bibliographic Details
Main Author: Espinoza-Fonseca L Michel
Format: Article
Language:English
Published: BMC 2005-09-01
Series:Theoretical Biology and Medical Modelling
Subjects:
multi-target drugs
RITA
cancer treatment
blind docking
MDM2
p53 tumor suppressor
Online Access:http://www.tbiomed.com/content/2/1/38

Internet

http://www.tbiomed.com/content/2/1/38

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