Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes

Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes

Trans-10,cis-12 conjugated linoleic acid (CLA) has previously been shown to be the CLA isomer responsible for CLA-induced reductions in body fat in animal models, and we have shown that this isomer, but not the cis-9,trans-11 CLA isomer, specifically decreased triglyceride (TG) accumulation in prima...

Full description

Bibliographic Details
Main Authors:	J.Mark Brown, Maria Sandberg Boysen, Søren Skov Jensen, Ron F. Morrison, Jayne Storkson, Renee Lea-Currie, Michael Pariza, Susanne Mandrup, Michael K. McIntosh
Format:	Article
Language:	English
Published:	Elsevier 2003-07-01
Series:	Journal of Lipid Research
Subjects:	conjugated linoleic acid fatty acids lipid metabolism glucose metabolism triglycerides peroxisome proliferator-activated receptor gamma
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520310907

Similar Items

Mechanisms of lipid droplet formation by conjugated linoleic acid (CLA) isomers and its effects on cell viability
by: Thiyam, Gayatri
Published: (2011)

Mechanisms of lipid droplet formation by conjugated linoleic acid (CLA) isomers and its effects on cell viability
by: Thiyam, Gayatri
Published: (2011)

The antioxidant and hypolipidemic effect of conjugated linoleic acid (CLA).
Published: (1999)

9cis,11trans conjugated linoleic acid (CLA) is synthesised and desaturated into conjugated 18:3 in bovine adipose tissues
by: D. Gruffat, et al.
Published: (2008-01-01)

Synthesis of three isomers of linoleic acid
by: Bruno, John Joseph
Published: (2018)

Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers[S]
by: Berenice Ortiz, et al.
Published: (2009-11-01)

A CLA enriched diet improves organ damage associated with the metabolic syndrome in spontaneous hypertensive rats
by: Ida Soto-Rodríguez, et al.
Published: (2011-03-01)

Effects of two supplementation levels of linseed combined with CLA or tallow on meat quality traits and fatty acid profile of adipose and different muscle tissues in slaughter pigs
by: G. Bee, et al.
Published: (2008-01-01)

The effects of conjugated linoleic acid (CLA) isomers on obesity-related hypertension: insight into possible mechanisms involving adipocyte function
by: DeClercq, Vanessa
Published: (2010)

The effects of conjugated linoleic acid (CLA) isomers on obesity-related hypertension: insight into possible mechanisms involving adipocyte function
by: DeClercq, Vanessa
Published: (2010)

Production of conjugated linoleic acid and conjugated linolenic acid by Bifidobacterium breve JKL03 and its application
by: Jung, Yun-Kyoung, 1979-
Published: (2005)

The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis
by: Boyeon Kim, et al.
Published: (2016-08-01)

Fatty acid intake and rumen fatty acid composition is affected by pre-grazing herbage mass and daily herbage allowance in Holstein dairy cows
by: Rafael A. Palladino, et al.
Published: (2014-07-01)

Conjugated Linoleic Acid and Brain Metabolism: A Possible Anti-Neuroinflammatory Role Mediated by PPARα Activation
by: Elisabetta Murru, et al.
Published: (2021-01-01)

CLA antioxidant or prooxidant?
by: S. Cruz Pardos, et al.
Published: (2000-08-01)

Conjugated linoleic acid (CLA). Cis 9, trans 11 and trans 10, cis 12 isomer detection in crude and refined corn oils by capillary GC
by: Özlem Tokuşoğlu
Published: (2008-06-01)

Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
by: Strand Elin, et al.
Published: (2012-06-01)

Production, purification and characterization of a CLA-forming enzyme from Lactobacillus acidophilus
by: Wu, Haifeng, 1967-
Published: (2001)

SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARΔ expression in mice[S]
by: Michael P. Rogowski, et al.
Published: (2013-10-01)

13-(S)-Hydroxyoctadecadienoic acid (13-HODE) incorporation and conversion to novel products by endothelial cells1
by: Xiang Fang, et al.
Published: (1999-04-01)

Dietary Fat Quality and Metabolic Syndrome in Post-Menopausal Women
by: Mims, Sheryl D.
Published: (2011)

Identification of peroxisome proliferator-activated receptor alpha (PPARα)-dependent genes involved in hepatic lipid metabolism by fluorescent differential display.
Published: (2003)

Influence of conjugated linoleic acid (CLA) on intramuscular fatty acid composition in rabbit
by: C. Corino, et al.
Published: (2010-01-01)

15-Deoxy-Δ12,14-prostaglandin J2-induced apoptosis does not require PPARγ in breast cancer cells
by: Carl E. Clay, et al.
Published: (2002-11-01)

A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases
by: Mary C. Hunt, et al.
Published: (2005-09-01)

Peroxisomal Disorders and Their Mouse Models Point to Essential Roles of Peroxisomes for Retinal Integrity
by: Yannick Das, et al.
Published: (2021-04-01)

Pros and cons of CLA consumption: an insight from clinical evidences
by: Benjamin, Sailas, et al.
Published: (2015)

Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-α signaling
by: Soke Chee Kwong, et al.
Published: (2019-11-01)

Mucosal IgA increase in rats by continuous CLA feeding during suckling and early infancy
by: Francisco J. Pérez-Cano, et al.
Published: (2009-03-01)

Pelleting and sodium monensin increase milk CLA concentration from dairy cows fed flaxseed
by: Jakeline Vieira Romero, et al.

Effect of feeding sows on rations enriched with conjugated linoleic acid (CLA) and the growth capacity and survival of their piglets
by: Zdeněk Hadaš, et al.
Published: (2012-01-01)

ÁCIDO LINOLEICO CONJUGADO (CLA) E EXERCÍCIO FÍSICO: EFEITOS NA COMPOSIÇÃO CORPORAL
by: Juliane Barroso Leal, et al.
Published: (2014-04-01)

Concentrations of Conjugated Linoleic Acid Isomers in Human Plasma Reflect Intake of Dairy Products with Enhanced cis-9, trans-11 or tran-10, cis-12 Isomer Content
by: Shafer, Brian David
Published: (2014)

Effects of Cla and Camelina Sativa Seed Oil on Bone Properties in Broiler Chickens
by: Puzio Iwona, et al.
Published: (2012-03-01)

The modulating effect of conjugated linoleic acid (CLA) on cancer cell survival in vitro
by: Arendse, Lyle
Published: (2015)

Effects of trans n-6 fatty acids on the fatty acid profile of tissues and liver microsomal desaturation in the rat
by: Olivier Berdeaux, et al.
Published: (1996-04-01)

Efeito da suplementação com ácido linoléico conjugado (CLA) na composição do leite, no perfil de ácidos graxos e na atividade de enzimas lipogênicas em ratas lactantes.
by: Amanda Aparecida Hayashi
Published: (2003)

Efeito da suplementação com ácido linoléico conjugado (CLA) na composição do leite, no perfil de ácidos graxos e na atividade de enzimas lipogênicas em ratas lactantes.
by: Hayashi, Amanda Aparecida
Published: (2003)

Deposição de ácido linoléico conjugado (CLA) em tilápias-do-nilo Deposition of conjugated linoleic acid (CLA) in Nile tilapia
by: Lilian Dena dos Santos, et al.
Published: (2007-10-01)

Conjugated linoleic acid (CLA): effect modulation of body composition and lipid profile El ácido linoleico conjugado (CLA): los efectos en la modulación de la composición corporal y en el perfil lipídico
by: A. Baddini Feitoza, et al.
Published: (2009-08-01)