Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs

Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs

Telomeres, the natural ends of chromosomes, hide the linear telomeric DNA from constitutive exposure to the DNA damage response with a lariat structure or t-loop. Progressive telomere shortening associated with DNA replication in the absence of a compensatory mechanism culminates in t-loop collapse...

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Bibliographic Details
Main Authors: Aina Bernal, Elisenda Zafon, Daniel Domínguez, Enric Bertran, Laura Tusell
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
human mammary epithelial cells
telomere dysfunction
chromosome instability
p53
hTERT
cancer
Online Access:http://www.mdpi.com/1422-0067/19/7/2078

Internet

http://www.mdpi.com/1422-0067/19/7/2078

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