A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent Oncogene

A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent Oncogene

Marek’s disease virus (MDV) is one of several oncogenic herpesviruses and causes fatal lymphomas in chickens. The current “gold standard” vaccine is the live-attenuated MDV strain CVI988/Rispens (CVI), which is widely used and efficiently prevents tumor formation. Intriguingly, CVI expresses two pre...

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Bibliographic Details
Main Authors: Andelé M. Conradie, Luca D. Bertzbach, Nirajan Bhandari, Mark Parcells, Benedikt B. Kaufer
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mSphere
Subjects:
vaccine
cvi988/rispens
marek’s disease virus (mdv)
tumorigenesis
t cell lymphoma
cancer
meq gene
basic leucine zipper (bzip) protein
herpesvirus telomerase rna (vtr)
Online Access:https://doi.org/10.1128/mSphere.00658-19

Internet

https://doi.org/10.1128/mSphere.00658-19

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