Cerebrospinal fluid β-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies

Cerebrospinal fluid β-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies

The autophagy–lysosomal degradation pathway plays a role in the onset and progression of neurodegenerative diseases. Clinical and genetic studies indicate that mutations of β-glucocerebrosidase represent genetic risk factors for synucleinopathies, including Parkinson's Disease (PD) and Dementia...

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Bibliographic Details
Main Authors: L. Parnetti, C. Balducci, L. Pierguidi, C. De Carlo, M. Peducci, C. D'Amore, C. Padiglioni, S. Mastrocola, E. Persichetti, S. Paciotti, G. Bellomo, N. Tambasco, A. Rossi, T. Beccari, P. Calabresi
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neurobiology of Disease
Subjects:
β-glucocerebrosidase
α-mannosidase
Lysosomal enzymes
Lysosomal hydrolases
Synucleinopathies
Cerebrospinal fluid
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000576

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http://www.sciencedirect.com/science/article/pii/S0969996109000576

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