The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage

The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts with hyaluronan to form large aggregates, which are responsible for the ability of the tissues to resist compressive loads. This function is...

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Bibliographic Details
Main Authors: P Roughley, D Martens, J Rantakokko, M Alini, F Mwale, J Antoniou
Format: Article
Language:English
Published: AO Research Institute Davos 2006-01-01
Series:European Cells & Materials
Subjects:
Online Access:http://www.ecmjournal.org/journal/papers/vol011/pdf/v011a01.pdf