A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood

A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood

The limited hemocompatibility of currently used oxygenator membranes prevents long-term use of artificial lungs in patients with lung failure. To improve hemocompatibility, we developed a novel covalent C1-esterase inhibitor (C1-INH) coating. Besides complement inhibition, C1-INH also prevents FXII...

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Bibliographic Details
Main Authors: Katharina Gerling, Sabrina Ölschläger, Meltem Avci-Adali, Bernd Neumann, Ernst Schweizer, Christian Schlensak, Hans-Peter Wendel, Sandra Stoppelkamp
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
ECMO
hollow-fiber membranes
C1-esterase inhibitor
anti-thrombogenic
novel coating
inflammation
Online Access:https://www.mdpi.com/2218-273X/10/7/1042

Internet

https://www.mdpi.com/2218-273X/10/7/1042

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