Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampusResearch in Context

Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampusResearch in Context

Background: NACHT and WD repeat domain-containing protein 1 (Nwd1) is a member of the innate immune protein subfamily. Nwd1 contributes to the androgen receptor signaling pathway and is involved in axonal growth. However, the mechanisms that underlie pathophysiological dysfunction in seizures remain...

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Main Authors: Qin Yang, Zifeng Huang, Yangfu Luo, Fangshuo Zheng, Yida Hu, Hui Liu, Shuzhen Zhu, Miaoqing He, Demei Xu, Yun Li, Min Yang, Yi Yang, Xiaobo Wei, Xiaoya Gao, Wei Wang, Junhong Ma, Yuanlin Ma, Xuefeng Wang, Qing Wang
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419305705

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http://www.sciencedirect.com/science/article/pii/S2352396419305705

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