Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress

Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress

Background: Neuroprotective effects of ketogenic diets (KD) have been reported in stroke models, and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has also been implicated in the pathogenesis of stroke. This study aimed to investigate the effects of KD on NLRP3 inflamm...

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Bibliographic Details
Main Authors: Min Guo, Xun Wang, Yanxin Zhao, Qi Yang, Hongyan Ding, Qiang Dong, Xingdong Chen, Mei Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ketogenic diet
β-hydroxybutyrate
mitochondrial fission
endoplasmic reticulum stress
NLRP3 inflammasome
Drp1
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00086/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00086/full

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