The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor.

The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor.

Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex (HLA) through the T-cell receptor (TCR). However, how a single amino acid substitution in the antigen bonded to HLA affects the response of T cells remains uncertain. Hence, we use...

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Bibliographic Details
Main Authors: Estefanía García-Guerrero, José Antonio Pérez-Simón, Luis Ignacio Sánchez-Abarca, Irene Díaz-Moreno, Miguel A De la Rosa, Antonio Díaz-Quintana
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4849770?pdf=render

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http://europepmc.org/articles/PMC4849770?pdf=render

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