Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway

Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway

Intracerebral hemorrhage (ICH) is a devastating disease with high rates of mortality and morbidity. The aim of this study was to explore whether Sodium Benzoate (NaB) could reduce neural cell apoptosis and alleviate neurological deficits after ICH. To assess the therapeutic effects of NaB, first, we...

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Bibliographic Details
Main Authors: Weilin Xu, Tao Li, Liansheng Gao, Cameron Lenahan, Jingwei Zheng, Jun Yan, Anwen Shao, Jianmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
DJ-1
sodium benzoate
intracerebral hemorrhage
secondary brain injury neuronal apoptosis
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00105/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00105/full

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