CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses

CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses

Studies have shown that blockade of CTLA-4 promoted the expansion of germinal center B-cells in viral infection or immunization with model antigens. Few studies have evaluated the immunological consequences of CTLA-4 blockade during immunization against relevant vaccine candidates. Here, we investig...

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Bibliographic Details
Main Authors: Phoebe E. Lewis, Ethan C. Poteet, Dongliang Liu, Changyi Chen, Celia C. LaBranche, Sherry A. Stanfield-Oakley, David C. Montefiori, Guido Ferrari, Qizhi Yao
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Vaccines
Subjects:
CTLA-4
HIV
vaccine
VLP
B-cell
Tfh
Online Access:https://www.mdpi.com/2076-393X/8/2/284

Internet

https://www.mdpi.com/2076-393X/8/2/284

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