Cancer-Associated Intermediate Conductance Ca2+-Activated K+ Channel KCa3.1

Cancer-Associated Intermediate Conductance Ca2+-Activated K+ Channel KCa3.1

Several tumor entities have been reported to overexpress KCa3.1 potassium channels due to epigenetic, transcriptional, or post-translational modifications. By modulating membrane potential, cell volume, or Ca2+ signaling, KCa3.1 has been proposed to exert pivotal oncogenic functions in tumorigenesis...

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Bibliographic Details
Main Authors: Corinna J. Mohr, Friederike A. Steudel, Dominic Gross, Peter Ruth, Wing-Yee Lo, Reiner Hoppe, Werner Schroth, Hiltrud Brauch, Stephan M. Huber, Robert Lukowski
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
KCa3.1
intermediate conductance calcium-activated K+ channel
BK
big conductance Ca2+- and voltage-activated K+ channels
TRAM-34
(1-[(2-chlorophenyl) diphenylmethyl]-pyrazole
1-EBIO
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
E2
17-estradiol
Online Access:http://www.mdpi.com/2072-6694/11/1/109

Internet

http://www.mdpi.com/2072-6694/11/1/109

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