Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

In a previous paper, we reported that triptolide (TP), a commonly used immunomodulator, could attenuate cardiac hypertrophy. This present study aimed to further explore the inhibition of cardiac fibrosis by TP and the possible mechanism from the perspective of the NOD-like receptor protein 3 (NLRP3)...

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Bibliographic Details
Main Authors: Xi-Chun Pan, Ya Liu, Yan-Yan Cen, Ya-Lan Xiong, Jing-Mei Li, Yuan-Yuan Ding, Yang-Fei Tong, Tao Liu, Xiao-Hong Chen, Hai-Gang Zhang
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
triptolide
cardiac fibrosis
inflammasome
NOD-like receptor protein 3
apoptosis-associated speck-like protein containing a CARD
Online Access:http://www.mdpi.com/1422-0067/20/2/360

Internet

http://www.mdpi.com/1422-0067/20/2/360

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