Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia.

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia.

The Birt-Hogg-Dubé (BHD) disease is a genetic cancer syndrome. The responsible gene, BHD, has been identified by positional cloning and thought to be a novel tumor suppressor gene. BHD mutations cause many types of diseases including renal cell carcinomas, fibrofolliculomas, spontaneous pneumothorax...

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Bibliographic Details
Main Authors: Jindong Chen, Kunihiko Futami, David Petillo, Jun Peng, Pengfei Wang, Jared Knol, Yan Li, Sok-Kean Khoo, Dan Huang, Chao-Nan Qian, Ping Zhao, Karl Dykema, Racheal Zhang, Brian Cao, Ximing J Yang, Kyle Furge, Bart O Williams, Bin Tean Teh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2570491?pdf=render

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http://europepmc.org/articles/PMC2570491?pdf=render

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