Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis

Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis

Cardiac fibroblasts play a key role in chronic heart failure. The conversion from cardiac fibroblast to myofibroblast as a result of cardiac injury, will lead to excessive matrix deposition and a perpetuation of pro-fibrotic signaling. Cardiac cell therapy for chronic heart failure may be able to ta...

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Bibliographic Details
Main Authors: Tom C. L. Bracco Gartner, Janine C. Deddens, Emma A. Mol, Marina Magin Ferrer, Linda W. van Laake, Carlijn V. C. Bouten, Ali Khademhosseini, Pieter A. Doevendans, Willem J. L. Suyker, Joost P. G. Sluijter, Jesper Hjortnaes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac fibrosis
cardiac tissue engineering
in vitro 3D models
cardiac progenitor cells
stem cell therapy
extracellular vesicles
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00052/full

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https://www.frontiersin.org/article/10.3389/fcvm.2019.00052/full

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