A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.

A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.

Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN) rat colony and was identified as causing marked T...

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Bibliographic Details
Main Authors: Marianne Chabod, Christophe Pedros, Lucille Lamouroux, Céline Colacios, Isabelle Bernard, Dominique Lagrange, Daniela Balz-Hara, Jean-Francois Mosnier, Christian Laboisse, Nathalie Vergnolle, Olivier Andreoletti, Marie-Paule Roth, Roland Liblau, Gilbert J Fournié, Abdelhadi Saoudi, Anne S Dejean
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3261907?pdf=render

Internet

http://europepmc.org/articles/PMC3261907?pdf=render

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