Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney

Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney

L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Drosophila larval development. L-2HG is known to be m...

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Bibliographic Details
Main Authors: Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M. Tennessen, Juan Liu, Jason W. Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L. Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K. Challa, Sunil Sudarshan
Format: Article
Language:English
Published: The Company of Biologists 2020-11-01
Series:Disease Models & Mechanisms
Subjects:
l-2-hydroxyglutarate
l-2-hydroxyglutarate dehydrogenase
tca cycle
ppargc1a
Online Access:http://dmm.biologists.org/content/13/11/dmm045898

Internet

http://dmm.biologists.org/content/13/11/dmm045898

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