Dopamine Levels Induced by Substance Abuse Alter Efficacy of Maraviroc and Expression of CCR5 Conformations on Myeloid Cells: Implications for NeuroHIV

Dopamine Levels Induced by Substance Abuse Alter Efficacy of Maraviroc and Expression of CCR5 Conformations on Myeloid Cells: Implications for NeuroHIV

Despite widespread use of antiretroviral therapy (ART), HIV remains a major public health issue. Even with effective ART many infected individuals still suffer from the constellation of neurological symptoms now known as neuroHIV. These symptoms can be exacerbated by substance abuse, a common comorb...

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Bibliographic Details
Main Authors: Stephanie M. Matt, Emily A. Nickoloff-Bybel, Yi Rong, Kaitlyn Runner, Hannah Johnson, Margaret H. O’Connor, Elias K. Haddad, Peter J. Gaskill
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
neuroHIV
macrophage
microglia
dopamine
drug abuse
CCR5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663061/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.663061/full

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