Bromo-Cyclobutenaminones as New Covalent UDP-<i>N</i>-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Bromo-Cyclobutenaminones as New Covalent UDP-<i>N</i>-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Drug discovery programs against the antibacterial target UDP-<i>N</i>-acetylglucosamine enolpyruvyl transferase (MurA) have already resulted in covalent inhibitors having small three- and five-membered heterocyclic rings. In the current study, the reactivity of four-membered rings was ca...

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Bibliographic Details
Main Authors: David J. Hamilton, Péter Ábrányi-Balogh, Aaron Keeley, László Petri, Martina Hrast, Tímea Imre, Maikel Wijtmans, Stanislav Gobec, Iwan J. P. de Esch, György Miklós Keserű
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
covalent inhibitor
MurA
cyclobutenaminone
antibacterial
irreversible
Online Access:https://www.mdpi.com/1424-8247/13/11/362

Internet

https://www.mdpi.com/1424-8247/13/11/362

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