Pre-immunization with an intramuscular injection of AAV9-human erythropoietin vectors reduces the vector-mediated transduction following re-administration in rat brain.

Pre-immunization with an intramuscular injection of AAV9-human erythropoietin vectors reduces the vector-mediated transduction following re-administration in rat brain.

We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in the substantia nigra in a rat model of Parkinson's disease. In the present study, we examined whether pre-exposure...

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Bibliographic Details
Main Authors: Chun Yang, Wei-Hua Yang, Sha-Sha Chen, Bao-Feng Ma, Bin Li, Tao Lu, Ting-Yu Qu, Ronald L Klein, Li-Ru Zhao, Wei-Ming Duan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3648480?pdf=render

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http://europepmc.org/articles/PMC3648480?pdf=render

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