Mutations in SRY and WT1 genes required for gonadal development are not responsible for XY partial gonadal dysgenesis

Mutations in SRY and WT1 genes required for gonadal development are not responsible for XY partial gonadal dysgenesis

The WT1 transcription factor regulates SRY expression during the initial steps of the sex determination process in humans, activating a gene cascade leading to testis differentiation. In addition to causing Wilms' tumor, mutations in WT1 are often responsible for urogenital defects in men, whil...

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Bibliographic Details
Main Authors: E.B. Tagliarini, J.G. Assumpção, M.R. Scolfaro, M.P. de Mello, A.T. Maciel-Guerra, G. Guerra Júnior, C. Hackel
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2005-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
XY partial gonadal dysgenesis
SRY open reading frame
SRY 5' untranslated region
WT1 exons
Denys-Drash syndrome
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100004

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100004

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