Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). Yet, it is not known how UPR-signaling coordinates adaptation versus cell death. Previous studies suggested that signaling through PERK/ATF4 is required for cell...

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Bibliographic Details
Main Authors: Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J Kaufman, Ze'ev A Ronai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4014425?pdf=render

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http://europepmc.org/articles/PMC4014425?pdf=render

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