S-thanatin functionalized liposome potentially targeting on Klebsiella pneumoniae and its application in sepsis mouse model

S-thanatin functionalized liposome potentially targeting on Klebsiella pneumoniae and its application in sepsis mouse model

S-thanatin (Ts) was a short antimicrobial peptide with selective antibacterial activity. In this study, we aimed to design a drug carrier with specific bacterial targeting potential. The positively charged Ts was modified onto the liposome surface by linking Ts to the constituent lipids via a PEG li...

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Bibliographic Details
Main Authors: Xiaobo eFan, Juxiang eFan, Xiyong eWang, Pengpeng eWu, Guoqiu eWu
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Pharmacology
Subjects:
Liposomes
Sepsis
multidrug resistance
antimicrobial peptides
targeting delivery
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00249/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00249/full

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