A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer

A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer

The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T cells and are implicated in the failure of immune...

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Bibliographic Details
Main Authors: Ameet A. Chimote, Vaibhavkumar S. Gawali, Hannah S. Newton, Trisha M. Wise-Draper, Laura Conforti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
ion channels
T cells
head and neck cancer
KCa3.1
calmodulin
T cell function
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00143/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00143/full

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