Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD are present in SARS-CoV-2 variants of concern that have emerged independently worldwide. For example, the B.1.1.7...

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Bibliographic Details
Main Authors: Michael I Barton, Stuart A MacGowan, Mikhail A Kutuzov, Omer Dushek, Geoffrey John Barton, P Anton van der Merwe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
COVID-19
SARS-CoV-2
ACE2
viral receptor
affinity
coronavirus
Online Access:https://elifesciences.org/articles/70658

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