Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717. We investigated P2X7 availability, in comparison with availa...

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Bibliographic Details
Main Authors: Melissa Crabbé, Anke Van der Perren, Ilse Bollaerts, Savannah Kounelis, Veerle Baekelandt, Guy Bormans, Cindy Casteels, Lieve Moons, Koen Van Laere
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
P2X7
translocator protein
6-OHDA
α-synuclein
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00799/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00799/full

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