High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

BACKGROUND:Many different genetic alterations are observed in cancer cells. Individual cancer genes display point mutations such as base changes, insertions and deletions that initiate and promote cancer growth and spread. Somatic hypermutation is a powerful mechanism for generation of different mut...

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Bibliographic Details
Main Authors: Vladimir I Kashuba, Tatiana V Pavlova, Elvira V Grigorieva, Alexey Kutsenko, Surya Pavan Yenamandra, Jingfeng Li, Fuli Wang, Alexei I Protopopov, Veronika I Zabarovska, Vera Senchenko, Klas Haraldson, Tatiana Eshchenko, Julia Kobliakova, Olga Vorontsova, Igor Kuzmin, Eleonora Braga, Vladimir M Blinov, Lev L Kisselev, Yi-Xin Zeng, Ingemar Ernberg, Michael I Lerman, George Klein, Eugene R Zabarovsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2684631?pdf=render

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http://europepmc.org/articles/PMC2684631?pdf=render

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