Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.

Bibliographic Details
Main Authors: Yunshu Wu, Liang Xie, Mengyuan Wang, Qiuchan Xiong, Yuchen Guo, Yu Liang, Jing Li, Rui Sheng, Peng Deng, Yuan Wang, Rixin Zheng, Yizhou Jiang, Ling Ye, Qianming Chen, Xuedong Zhou, Shuibin Lin, Quan Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06898-4

Internet

https://doi.org/10.1038/s41467-018-06898-4

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