In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.

In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.

<h4>Background</h4>Matrix metalloproteinases (MMPs) released by glial cells are important mediators of neuroinflammation and neurologic damage in HIV infection. The use of antiretroviral drugs able to combat the detrimental effect of chronic inflammation and target the exaggerated MMP ac...

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Bibliographic Details
Main Authors: Pasqua Gramegna, Tiziana Latronico, Maria Teresa Branà, Gaetano Di Bari, Fabio Mengoni, Valeria Belvisi, Maria T Mascellino, Miriam Lichtner, Vincenzo Vullo, Claudio M Mastroianni, Grazia M Liuzzi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174822/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174822/?tool=EBI

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