Differential angiogenic gene expression in TP53 wild-type and mutant ovarian cancer cell lines

Differential angiogenic gene expression in TP53 wild-type and mutant ovarian cancer cell lines

Objectives: Underlying mechanisms regulating angiogenesis in ovarian cancer have not been completely elucidated. Evidence suggests that the TP53 tumor suppressor pathway and tumor microenvironment play integral roles. We utilized microarray technology to study the interaction between TP53 mutational...

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Bibliographic Details
Main Authors: Brittany Anne Davidson, Jennifer eRubatt, David eCorcoran, Deanna eTeoh, Marcus eBernadini, Lisa eGrace, John William Soper, Andrew eBerchuck, Sharareh eSiamakpour-Reihani, Wei eChen, Kouros eOwzar, Susan eMurphy, Angeles Alvarez Secord
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Oncology
Subjects:
VEGF
hypoxia
Angiogenesis
ovarian cancer
TP53
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00163/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00163/full

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