Identification of BACE2 as an avid ß-amyloid-degrading protease

Identification of BACE2 as an avid ß-amyloid-degrading protease

<p>Abstract</p> <p>Background</p> <p>Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-de...

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Bibliographic Details
Main Authors: Abdul-Hay Samer O, Sahara Tomoko, McBride Melinda, Kang Dongcheul, Leissring Malcolm A
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Molecular Neurodegeneration
Subjects:
Amyloid-ß-protein
Alzheimer disease
ß-site APP-cleaving enzyme-1
ß-site APP-cleaving enzyme-2
Functional screen
Gene therapy
Protease
Proteolytic degradation
Online Access:http://www.molecularneurodegeneration.com/content/7/1/46

Internet

http://www.molecularneurodegeneration.com/content/7/1/46

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