Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR/PI3K/AKT/m-TOR pathway

Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR/PI3K/AKT/m-TOR pathway

Rheumatoid arthritis (RA) is a chronic autoimmune disease in which synovial fibroblast-like cells (FLSs) play an important role in RA development and is known to be lack of effective therapy. Thus, novel therapeutic strategies are greatly needed for treatment of RA. Metformin, a first-line drug for...

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Bibliographic Details
Main Authors: Kun Chen, Zhao-Wei Lin, Sheng-mao He, Cheng-qiang Wang, Jian-cheng Yang, Yao Lu, Xiao-bo Xie, Qi Li
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Metformin
Proliferation
Cell cycle
Rheumatoid arthritis
Fibroblast-like synoviocytes
IGF-IR /PI3K/AKT/ mTOR pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218327367

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http://www.sciencedirect.com/science/article/pii/S0753332218327367

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