A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer

A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer

Oncolytic viruses armed with therapeutic transgenes of interest show great potential in cancer immunotherapy. Here, a novel oncolytic adenovirus carrying a signal regulatory protein‐α (SIRPα)‐IgG1 Fc fusion gene (termed SG635‐SF) was constructed, which could block the CD47 ‘don't eat me’ signal...

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Bibliographic Details
Main Authors: Yao Huang, Sai‐qun Lv, Pin‐yi Liu, Zhen‐long Ye, Huan Yang, Lin‐fang Li, Hai‐li Zhu, Ying Wang, Lian‐zhen Cui, Du‐qing Jiang, Fang‐yuan Hao, Hui‐min Xu, Hua‐jun Jin, Qi‐jun Qian
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Molecular Oncology
Subjects:
cancer immunotherapy
CD47
oncolytic virus
ovarian cancer
SIRPα
Online Access:https://doi.org/10.1002/1878-0261.12628

Internet

https://doi.org/10.1002/1878-0261.12628

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